TCHP antibody (70R-10097)

Affinity purified rabbit polyclonal TCHP antibody

Synonyms Polyclonal TCHP antibody, Anti-TCHP antibody, MGC10854 antibody, keratin filament binding antibody, trichoplein
Cross Reactivity Human
Applications WB
Immunogen TCHP antibody was raised in rabbit using the C terminal of TCHP as the immunogen
Assay Information TCHP Blocking Peptide, catalog no. 33R-4111, is also available for use as a blocking control in assays to test for specificity of this TCHP antibody

Images

Western Blot analysis using TCHP antibody (70R-10097)

Western Blot showing TCHP antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

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Images

  • Western Blot analysis using TCHP antibody (70R-10097) | Western Blot showing TCHP antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Availability: In stock

Price: £276.43
Size: 50 ug
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