TCHP antibody (70R-10097)
Affinity purified rabbit polyclonal TCHP antibody
|Synonyms||Polyclonal TCHP antibody, Anti-TCHP antibody, MGC10854 antibody, keratin filament binding antibody, trichoplein|
|Immunogen||TCHP antibody was raised in rabbit using the C terminal of TCHP as the immunogen|
|Assay Information||TCHP Blocking Peptide, catalog no. 33R-4111, is also available for use as a blocking control in assays to test for specificity of this TCHP antibody|
Western Blot analysis using TCHP antibody (70R-10097)
Western Blot showing TCHP antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.|
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