TCL1A protein (30R-1391)
Purified recombinant Human TCL1A protein
|Synonyms||TCL 1 protein protein, T cell leukemia 1 protein, TCLA-1 protein, TCL1A, TCLA 1, TCL-1 protein, TCL1A protein, TCL1 oncogene protein, P14 TCL1 protein protein, protein p14TCL1 protein, TCL1 PEN protein, TCLA 1 protein, Oncogene TCL1 protein, T-cell leukemia/lymphoma 1A anti TCL1A protein, T cell lymphoma 1A protein, TCL1A., TCL1 protein, T cell lymphoma 1 protein, P14 TCL1 protein, TCLA-1|
Coomassie Blue stained SDS-PAGE of TCL1A protein (30R-1391)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-114 amino acids: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD|
|Grade & Purity||> 90% pure|
|Molecular Weight||13.4 kDa (114aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 50mM Tris-HCl buffer, pH 7.5, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E. coli and purified by using conventional chromatography techniques|
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