TDP1 antibody (10R-1154)

Mouse monoclonal TDP1 antibody

Synonyms Monoclonal TDP1 antibody, Anti-TDP1 antibody, TDP-1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, FLJ11090 antibody, TDP 1, TDP 1 antibody, SCAN1 antibody, TDP1, TDP-1
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen TDP1 antibody was raised in mouse using recombinant human TDP1 (1-298aa) purified from E. coli as the immunogen.

Images

Western Blot analysis of TDP1 antibody (10R-1154)

Cell lysates of MCF7 (30 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human TDP1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Host Mouse
Clone AT1F2
Isotype IgG2b kappa
Source Anti-human TDP1 antibody, clone AT1F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TDP1 protein.
Method of Purification TDP1 antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:1,000-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.

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Images

  • Western Blot analysis of TDP1 antibody (10R-1154) | Cell lysates of MCF7 (30 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human TDP1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Availability: In stock

Price: £212.33
Size: 100 ul
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