TGF beta 1 protein (30R-AT027)

Purified recombinant Human TGF beta 1 protein

Synonyms TGF beta-1 protein, Differentiation inhibiting factor protein, TGFB1 protein, TGF beta 1 protein, TGF beta -1 protein, Transforming Growth Factor-beta1 protein, TGF beta 1, Cartilage-inducing factor protein, TGF beta -1, TGF-1b protein, TGF beta 1
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TGF beta 1 protein corresponding to amino acids ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS.
Expression System CHO cells
Grade & Purity > 98% pure
Form & Buffer Lyophilized from 10mM Sodium Citrate, pH 3.5. Reconstitute in 10 mM Citric Acid pH 3.0 .

Usage & Assay Information

Bioactivity The ED50 was determined by TGF-beta1?s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is approximately 0.05 ng/ml, corresponding to a specific activity of approximately 2 x 10^7 units/mg

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance The three mammalian isoforms of TGF beta, TGF beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1.

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Availability: In stock

Price: £180.28
Size: 5 ug
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