TNF beta protein (30R-AT047)

Purified recombinant Human TNF beta protein

Synonyms LT-alpha protein, TNFSF1 protein, TNF-b protein, Tumor Necrosis Factor-beta protein, TNF-beta protein, Lymphotoxin-alpha protein, TNFb protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TNF beta protein corresponding to amino acids MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 18.6 kDa
Form & Buffer Lyophilized from 10mM Na3PO4, pH 7.0, with 50 mM NaCl. Reconstitute in Water to a concentration of 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity The ED50 as determined by the cytolysis of Mouse L929 cells in the presence of Actinomycin-D is approximately 0.05 ng/ml, corresponding to a specific activity of approximately 2 x 10^7 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: £180.28
Size: 20 ug
OR
Shipping
View Our Distributors