TNFSF15 protein (His tag) (80R-1806)
Purified recombinant Human TNFSF15 protein
|Synonyms||TNFSF-15, VEGI192A protein, VEGI protein, TNFSF 15, TNFSF-15 protein, TNFSF15, TL1A protein, TL1 protein, Tumor necrosis factor ligand superfamily member 15 protein, TNFSF 15 protein|
Coomassie Blue stained SDS-PAGE of TNFSF15 protein (His tag) (80R-1806)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||72-251 amino acids: MGSSHHHHHH SSGLVPRGSH MLKGQEFAPS HQQVYAPLRA DGDKPRAHLT VVRQTPTQHF KNQFPALHWE HELGLAFTKN RMNYTNKFLL IPESGDYFIY SQVTFRGMTS ECSEIRQAGR PNKPDSITVV ITKVTDSYPE PTQLLMGTKS VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK EDKTFFGAFL L|
|Grade & Purity||> 95% pure|
|Molecular Weight||22.7 kDa (201aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0,containing 1mM DTT, 50% glycerol and 0.2M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Tumor necrosis factor ligand superfamily member 15, also known TNFSF15, belongs to the TNF superfamily. TNFSF15 is predominantly expressed in endothelial cells and its expression is inducible by TNF alpha and IL1 alpha. TNFSF15 is an angiogenesis inhibitor of the TNF family and functions in part by directly inhibiting endothelial cell proliferation. TNFSF15 may act as an autocrine factor to induce apoptosis in endothelial cells via activation of multiple signaling pathways, including stress protein kinases and certain caspases. Recombinant human TNFSF15 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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