TRAIL Receptor 2 protein (30R-AS051)

Purified recombinant Human TRAIL Receptor 2 protein

Synonyms TRICK2A protein, soluble TRAIL Receptor-2 protein, TNFRSF10B protein, KILER protein, TRAIL R2 protein, TRAIL R2 protein, TRAIL Receptor-2 protein, TRICKB protein, DR5 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TRAIL Receptor 2 protein corresponding to amino acids MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 22.7 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its inhibitory effect of IL-8 production in human PBMC by human sTRAIL/Apo2L. 50% inhibition (100 ng/ml of sTRAIL/Apo2L) was reached using a concentration of 1000 ng/ml of sTRAIL Receptor-2.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L.

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Availability: In stock

Price: £180.28
Size: 50 ug
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