Troponin I protein (Cardiac) (30R-AT034)

Purified native Human Troponin I protein (Cardiac)

Species Human
Protein Type Native
Applications User optimized

Specifications

Source Human cardiac tissue
Molecular Weight 100 kDa
Form & Buffer Supplied frozen in 25mM TRIS buffer, pH 7.5, with 150mM NaCl, and 0.09% NaN3. 0.1-5% of the total protein is Troponin I.
Concentration Batch dependent - please inquire should you have specific requirements

Storage & Safety

Storage Aliquot and store at -20 deg C. Avoid repeated freeze/thaw cycles
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.

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Availability: In stock

Price: £1,117.74
Size: 1 mg
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