Troponin T protein (His tag) (80R-1156)
Purified recombinant Human Troponin T protein
|Synonyms||MGC3889 protein, Troponin T type 2 (cardiac) protein, TnTC protein, CMPD2 protein, CMH2 protein, cardiac isoform 3 Cardiac muscle troponin T protein, Troponin T cardiac muscle protein, Cardiomyopathy hypertrophic 2 protein, RCM3 protein, Troponin T2 cardiac., Troponin T type 2 cardiac protein, Troponin T type 2 protein, CMD1D protein, TNNT2 protein, TNNT 2 protein, cTnT protein, cardiac isoform 3 protein, Cardiomyopathy dilated 1D (autosomal dominant) protein, Troponin T type 2 protein|
Coomassie Blue stained SDS-PAGE of Troponin T protein (His tag) (80R-1156)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-285 amino acids: MGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK|
|Grade & Purity||> 90% pure|
|Molecular Weight||36.4 kDa (305aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Troponin T, also known as TNNT2, is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with restrictive and dilated cardiomyopathy. Recombinant human TNNT2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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