TSLP protein (30R-AT044)

Purified recombinant Human TSLP protein

Synonyms Thymic Stromal Lymphopoietin protein, TSLP protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TSLP protein corresponding to amino acids MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKE MFAMKTKAAL AIWCPGYSET QINATQAMKK RRKRKVTTNK CLEQVSQLQG L WRRFNRPL LKQQ.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 15.0 kDa
Form & Buffer Lyophilized from NaC2H3O2, pH 6.0. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL7 and binds with the heterodimeric receptor complex consisting of the IL7R alpha chain (IL7Ra) and the TSLP-specific chain (TSLPR). Like IL7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs).

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Availability: In stock

Price: £180.28
Size: 10 ug
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