TWEAK Receptor protein (30R-AT080)

Purified recombinant Human TWEAK Receptor protein

Synonyms FGF-inducible 14 protein, TNF-related weak inducer of apoptosis receptor protein, TNFRSF12A protein
Species Human
Protein Type Recombinant
Applications User optimized


Residues Region of TWEAK protein corresponding to amino acids EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 5.6 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 ug/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TWEAKR belongs to the TNF family of transmembrane proteins and contains a cytoplasmic "death domain", which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK.

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Availability: In stock

Price: £163.51
Size: 25 ug
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