UBE2D1 protein (His tag) (80R-1830)
Purified recombinant UBE2D1 protein
|Synonyms||UBED1 2, UBED1-2 protein, UBED1 2 protein, UBED1-2, SFT protein, UBCH5 protein, UBE2D1, UBCH5A protein, UBC5A protein, Ubiquitin-conjugating enzyme E2D 1 protein|
Coomassie Blue stained SDS-PAGE of UBE2D1 protein (His tag) (80R-1830)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-147 amino acids: MGSSHHHHHH SSGLVPRGSH MGSMALKRIQ KELSDLQRDP PAHCSAGPVG DDLFHWQATI MGPPDSAYQG GVFFLTVHFP TDYPFKPPKI AFTTKIYHPN INSNGSICLD ILRSQWSPAL TVSKVLLSIC SLLCDPNPDD PLVPDIAQIY KSDKEKYNRH AREWTQKYAM|
|Grade & Purity||> 95% pure|
|Molecular Weight||19.0 kDa (170aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 40% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||UBE2D1 belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. UBE2D1 is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Recombinant human UBE2D1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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