UBE2L6 protein (His tag) (80R-1086)
Purified recombinant Human UBE2L6 protein
|Synonyms||UBEL6 2 protein, RIG B protein, UBCH8 protein, UBEL6-2 protein, UBE2L6, RIG-B protein, UBEL6-2, Retinoic acid induced gene B protein protein, Ubiquitin carrier protein L6 protein, UBEL6 2, UBE2L6 protein, Ubiquitin conjugating enzyme E2L 6 protein, UBCH 8 protein, Ubiquitin conjugating enzyme E2L 6 MGC40331 protein, Ubiquitin carrier protein protein, Ubiquitin protein ligase L6 protein, Ubiquitin/ISG15 conjugating enzyme E2 L6., Ubiquitin protein ligase protein|
Coomassie Blue stained SDS-PAGE of UBE2L6 protein (His tag) (80R-1086)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-152 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS|
|Grade & Purity||> 90% pure|
|Molecular Weight||21.7 kDa (188aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 1mM DTT, 0.1mM PMSF, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Ubiquitin-conjugating enzyme E2L6 (UBE2L6), also known as UbcH8, is a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination of a protein substrate requires the concerted action of 3 classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. The E2 ubiquitin-conjugating enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Recombinant human UBE2L6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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