VHL protein, betadomain protein (His tag) (80R-1008)

Purified recombinant Human VHL protein, betadomain protein

Synonyms HRCA1 protein, RCA1 protein, VHL 1 protein, VHL1 protein, G7 protein protein, Von Hippel-Lindau tumor suppressor isoform 1 protein, von Hippel Lindau tumor suppressor protein, Von Hippel-Lindau tumor suppressor isoform 1 pVHL protein, RCA 1 protein, HRCA 1 protein, , VHLH protein, von Hippel Lindau syndrome protein, Elongin binding protein protein, Von Hippel Lindau disease tumor suppressor protein, VHL protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of VHL protein, betadomain protein (His tag) (80R-1008)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-154 amino acids: MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP
Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 19.2 kDa (174 aa), confirmed by MALDI-TOF.
Tag/Conjugate His tag
Form & Buffer Supplied as a liquid in PBS, pH 7.4, containing 2mM EDTA.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Von Hippel-Lindau disease(VHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). VHL beta-domain(1-154aa) was overexpressed in E. coli and purified by using conventional chromatography techniques

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Images

  • Coomassie Blue stained SDS-PAGE of VHL protein, betadomain protein (His tag) (80R-1008) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: £144.23
Size: 100 ug
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