Visininlike protein1 protein (30R-1384)
Purified recombinant Human Visininlike protein1 protein
|Synonyms||Neurocalcin alpha protein, Visinin.Visinin like 1 protein, HLP3 protein, NVL1 protein, Visininlike 1, HLP 3 protein, Visinin like protein 1.VISL 1., NVL 1 protein, VILIP-1 protein, VILIP protein, VILIP protein, HPCAL 3 protein, Visininlike -1 protein, Visininlike -1, Visininlike 1, VSNL1 protein, Visininlike 1 protein, Hippocalcin like protein 3 protein, HUVISL1 protein, VLP-1 protein, HPCAL3 protein|
Coomassie Blue stained SDS-PAGE of Visininlike protein1 protein (30R-1384)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-191 amino acids: MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K|
|Grade & Purity||> 95% pure|
|Molecular Weight||22.1 kDa (191aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Visinin-like protein-1, also known as VILIP-1, belongs to a family of neuronal calcium sensor proteins. VILIP-1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Also, it is expressed in pancreatic beta-cells. VILIP-1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. Recombinant human Visinin-like protein-1 was expressed in E. coli and purified by using conventional chromatography.|
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