WIBG antibody (70R-10101)

Affinity purified rabbit polyclonal WIBG antibody

Synonyms Polyclonal WIBG antibody, Anti-WIBG antibody, PYM antibody, MGC13064 antibody, within bgcn homolog, Drosophila antibody
Cross Reactivity Human
Applications WB
Immunogen WIBG antibody was raised in rabbit using the C terminal of WIBG as the immunogen
Assay Information WIBG Blocking Peptide, catalog no. 33R-4474, is also available for use as a blocking control in assays to test for specificity of this WIBG antibody

Images

Western Blot analysis using WIBG antibody (70R-10101)

Western Blot showing WIBG antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance WIBG is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. It acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. It interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions.

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Images

  • Western Blot analysis using WIBG antibody (70R-10101) | Western Blot showing WIBG antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Availability: In stock

Price: £276.43
Size: 50 ug
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